Iron overload

Definition

Iron overload is a condition where excess iron accumulates in the body, potentially leading to toxic effects and organ damage. It is often caused by genetic disorders or repeated blood transfusions.

5 Must Know Facts For Your Next Test

1. Hemochromatosis is a primary cause of iron overload and can be inherited genetically.
2. Symptoms of iron overload include fatigue, joint pain, abdominal pain, and skin discoloration.
3. Excess iron can deposit in organs like the liver, heart, and pancreas, leading to severe complications such as cirrhosis or diabetes.
4. Phlebotomy (regular blood removal) is a common treatment for managing iron levels in patients with iron overload.
5. Dietary modifications, including reducing red meat intake and avoiding vitamin C supplements that increase iron absorption, are crucial for managing iron overload.

Review Questions

• What are the possible causes of iron overload?
• Which organs are primarily affected by excess iron accumulation?
• How can dietary changes help manage iron overload?

Related terms

Hemochromatosis:

A genetic disorder causing excessive absorption of dietary iron.

Phlebotomy:

A procedure involving the removal of blood to reduce excess iron levels.

Cirrhosis:

Liver damage characterized by scarring and impaired function, which can be a complication of untreated iron overload.