Haptoglobin

Definition

Haptoglobin is a plasma protein that binds free hemoglobin released from erythrocytes, preventing kidney damage and iron loss. It plays a crucial role in the body's response to hemolysis and inflammation.

5 Must Know Facts For Your Next Test

1. Haptoglobin levels decrease in conditions involving excessive red blood cell breakdown, such as hemolytic anemia.
2. Low haptoglobin levels can indicate intravascular hemolysis, while normal or high levels are seen in non-hemolytic anemias.
3. Chronic diseases like liver cirrhosis can also reduce haptoglobin levels due to decreased production.
4. Haptoglobin is an acute-phase reactant, meaning its levels increase in response to inflammation or infection.
5. Assessment of haptoglobin levels can help differentiate between different types of anemia and guide appropriate nutritional interventions.

Review Questions

• What does a low level of haptoglobin indicate in the context of hematological health?
• Why might haptoglobin be elevated during inflammation or infection?
• How can measuring haptoglobin levels aid in diagnosing types of anemia?

Related terms

Hemolytic Anemia: A condition where red blood cells are destroyed faster than they can be made.

Acute-Phase Reactant: Proteins whose plasma concentrations increase or decrease in response to inflammation.

Erythrocytes: Another term for red blood cells, responsible for carrying oxygen throughout the body.