Folate

Definition

Folate is a B-vitamin essential for DNA synthesis, repair, and methylation. It plays a crucial role in cell division and is particularly important during periods of rapid growth such as pregnancy and fetal development.

5 Must Know Facts For Your Next Test

1. Folate deficiency can lead to megaloblastic anemia, characterized by the production of abnormally large red blood cells.
2. Good dietary sources of folate include leafy green vegetables, legumes, nuts, and fortified cereals.
3. Folate is vital for neurological health; its deficiency has been linked to cognitive decline and increased risk of neural tube defects in newborns.
4. The synthetic form of folate used in supplements and food fortification is called folic acid.
5. Nurses should monitor folate levels in patients with conditions like celiac disease or Crohn's disease due to impaired absorption.

Review Questions

• What are some common dietary sources of folate?
• How does folate deficiency affect the hematologic system?
• Why is folate particularly important during pregnancy?

Related terms

Vitamin B12:

Essential for normal blood formation and neurological function; works closely with folate.

Megaloblastic Anemia:

A condition caused by improper red blood cell formation due to deficiencies in vitamin B12 or folate.

Neural Tube Defects:

Birth defects of the brain, spine, or spinal cord that occur due to inadequate maternal intake of folic acid before and during early pregnancy.