Elastase

Definition

Elastase is an enzyme produced by the pancreas that breaks down proteins, specifically elastin, during digestion. It plays a crucial role in the digestive process by aiding in the breakdown of dietary proteins into absorbable peptides and amino acids.

5 Must Know Facts For Your Next Test

1. Elastase is secreted by the pancreas into the small intestine.
2. It specifically targets and hydrolyzes elastin, a protein found in connective tissues.
3. Elastase activity can be measured in stool samples to assess pancreatic function.
4. A deficiency or malfunction of elastase can lead to malabsorption and digestive issues.
5. Elastase works optimally at an alkaline pH, which is maintained in the small intestine.

Review Questions

• What specific protein does elastase target during digestion?
• How can elastase activity be used to assess pancreatic function?
• Why is an optimal alkaline pH important for elastase function?

Related terms

Trypsin: An enzyme that also breaks down proteins but targets different peptide bonds than elastase.

Chymotrypsin: Another pancreatic enzyme that digests proteins, working synergistically with trypsin and elastase.

Pancreatic Amylase: An enzyme produced by the pancreas that breaks down carbohydrates into simple sugars during digestion.