Corticotropin-releasing hormone

Definition

Corticotropin-releasing hormone (CRH) is a peptide hormone involved in the stress response. It stimulates the release of adrenocorticotropic hormone (ACTH) from the anterior pituitary gland.

5 Must Know Facts For Your Next Test

1. CRH is produced by the hypothalamus and plays a crucial role in the hypothalamic-pituitary-adrenal (HPA) axis.
2. It helps regulate metabolism, immune response, and energy balance through its influence on cortisol levels.
3. Nutritional deficiencies, such as lack of adequate protein or specific vitamins, can impact CRH production and function.
4. Elevated levels of CRH are associated with chronic stress, which can lead to various health issues including endocrine disorders.
5. Proper nutrition can help modulate CRH levels and support overall endocrine health.

Review Questions

• What role does corticotropin-releasing hormone play in the HPA axis?
• How can nutritional deficiencies impact CRH production?
• Why are elevated levels of CRH associated with chronic stress?

Related terms

Hypothalamus:

A region of the brain that produces hormones that control many bodily functions, including hunger, thirst, and temperature regulation.

Adrenocorticotropic Hormone (ACTH): A hormone produced by the anterior pituitary gland that stimulates the adrenal glands to release cortisol.

Cortisol:

A steroid hormone released by the adrenal glands in response to stress; it has numerous roles including regulating metabolism and immune response.