Colchicine

Definition

Colchicine is a medication that inhibits microtubule polymerization, commonly used to treat gout and familial Mediterranean fever. It has anti-inflammatory properties but can be toxic at high doses.

5 Must Know Facts For Your Next Test

1. Colchicine can interfere with vitamin B12 absorption, which is crucial for neurological health.
2. It is metabolized by the liver and excreted by the kidneys, necessitating caution in patients with hepatic or renal impairments.
3. The drug can cause gastrointestinal side effects such as nausea, vomiting, and diarrhea.
4. Chronic use of colchicine may lead to neuromuscular toxicity, including myopathy and neuropathy.
5. Patients on colchicine should be monitored for signs of bone marrow suppression, a rare but serious side effect.

Review Questions

• How does colchicine affect vitamin B12 absorption?
• What are the potential neurological side effects of chronic colchicine use?
• Why should liver and kidney function be monitored in patients taking colchicine?

Related terms

Gout: A form of arthritis characterized by severe pain and inflammation due to uric acid crystal deposition.

Vitamin B12: An essential nutrient important for nerve function and blood cell production.

Myopathy: A disorder involving muscle weakness or dysfunction, which can be a side effect of certain medications like colchicine.