Pimecrolimus is a topical calcineurin inhibitor used primarily in the treatment of atopic dermatitis, also known as eczema. It works by inhibiting the activation of T-cells and the release of inflammatory cytokines, which helps to reduce inflammation and itchiness associated with skin conditions. Its role extends to drug-eluting stents, where it is incorporated into the coating to prevent restenosis by suppressing the immune response and limiting neointimal hyperplasia.
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