Solvaldi
from class: Microbiology Definition Sovaldi is an antiviral medication used to treat hepatitis C virus (HCV) infection. It works by inhibiting the RNA polymerase enzyme, which is essential for viral replication.
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Predict what's on your test 5 Must Know Facts For Your Next Test Sovaldi's generic name is sofosbuvir. It specifically targets the NS5B polymerase of the hepatitis C virus. Sovaldi must be used in combination with other antiviral medications and is not effective as monotherapy. It has a high cure rate, often exceeding 90% when combined with other drugs like ribavirin or ledipasvir. The drug was approved by the FDA in December 2013 and marked a significant advancement in HCV treatment. Review Questions What enzyme does Sovaldi inhibit to stop HCV replication? Why must Sovaldi be used in combination with other medications? When was Sovaldi approved by the FDA and what impact did it have on HCV treatment?
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