Nifurtimox

Definition

Nifurtimox is an antiparasitic medication primarily used to treat Chagas disease, caused by Trypanosoma cruzi. It functions by generating free radicals that damage the DNA of the parasite.

5 Must Know Facts For Your Next Test

1. Nifurtimox is effective against the acute phase of Chagas disease.
2. It is one of the two primary drugs approved for treating Chagas disease, the other being benznidazole.
3. Common side effects include gastrointestinal issues and neurological symptoms like headache and dizziness.
4. Nifurtimox is not recommended for use in patients with severe renal or hepatic impairment.
5. The drug works by producing reactive oxygen species that are toxic to the parasite.

Review Questions

• What phase of Chagas disease is nifurtimox most effective against?
• What are some common side effects of nifurtimox?
• How does nifurtimox act on Trypanosoma cruzi at a cellular level?

Related terms

Trypanosoma cruzi: A parasitic protozoan that causes Chagas disease.

Benznidazole: Another antiparasitic medication used to treat Chagas disease.

Chagas Disease: An infectious disease caused by Trypanosoma cruzi, often transmitted through insect vectors.