Necrosis

Definition

Necrosis is the premature death of cells in living tissue caused by external factors such as infection, toxins, or trauma. It leads to the unregulated digestion of cell components, often resulting in inflammation.

5 Must Know Facts For Your Next Test

1. Necrosis can be a result of severe bacterial infections like gangrene, which affects tissues and organs.
2. In viral infections of the gastrointestinal tract, necrosis may occur due to the cytopathic effects of the virus on intestinal cells.
3. Unlike apoptosis, necrosis triggers an inflammatory response that can exacerbate tissue damage and disease symptoms.
4. Common signs of necrotic tissue include discoloration, swelling, and a foul odor due to bacterial activity.
5. Effective treatment for necrosis often involves removing dead tissue to prevent further spread of infection.

Review Questions

• What are some external factors that can cause necrosis?
• How does necrosis differ from apoptosis regarding cellular response?
• Why is it crucial to remove necrotic tissue during treatment?

Related terms

Apoptosis: Programmed cell death that occurs naturally as part of growth and development.

Gangrene: A serious condition where body tissue dies due to loss of blood supply or severe bacterial infection.

Inflammation: The body's immune response to injury or infection, often causing redness, warmth, swelling, and pain.