Mefloquine

Definition

Mefloquine is an antimalarial drug used to prevent and treat malaria. It works by interfering with the growth of parasites in the red blood cells.

5 Must Know Facts For Your Next Test

1. Mefloquine is effective against Plasmodium falciparum, the parasite responsible for most malaria-related deaths.
2. It is often used in regions where chloroquine-resistant malaria is prevalent.
3. Common side effects include dizziness, nausea, and vivid dreams or nightmares.
4. Mefloquine has a long half-life, which allows for weekly dosing when used as prophylaxis.
5. Resistance to mefloquine can arise due to mutations in the parasite’s genome, particularly in the pfmdr1 gene.

Review Questions

• What type of pathogen does mefloquine target?
• Why is mefloquine preferred in areas with chloroquine-resistant malaria?
• Name one common side effect associated with mefloquine usage.

Related terms

Chloroquine: An antimalarial drug that targets the same parasites but has different resistance profiles.

Plasmodium falciparum: The most dangerous species of Plasmodium causing severe forms of malaria.

Antimicrobial Resistance: The ability of microorganisms to withstand antimicrobial treatments such as antibiotics and antimalarials.