Chloroquine
from class:
Microbiology
Definition
Chloroquine is an antimalarial drug that also exhibits bactericidal properties. It interferes with the growth of parasites in the red blood cells.
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5 Must Know Facts For Your Next Test
- Chloroquine works by inhibiting heme polymerase activity in malaria parasites, leading to toxic buildup.
- It is primarily used to prevent and treat malaria caused by Plasmodium parasites.
- Besides its antimalarial effects, chloroquine has shown effectiveness against certain viral infections and inflammatory diseases.
- Resistance to chloroquine has emerged, particularly in Plasmodium falciparum strains.
- The drug can cause side effects such as gastrointestinal distress, headaches, and retinal toxicity with prolonged use.
Review Questions
- How does chloroquine inhibit the growth of malaria parasites?
- What are some non-malarial uses of chloroquine?
- What are the potential side effects associated with prolonged use of chloroquine?
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