Koilocytes

Definition

Koilocytes are abnormal epithelial cells with a characteristic appearance, often seen in Pap smears. They are indicative of human papillomavirus (HPV) infection.

5 Must Know Facts For Your Next Test

1. Koilocytes display a perinuclear halo and nuclear enlargement, which are hallmarks of HPV infection.
2. They are most commonly found in the anogenital region but can also be present in other mucosal surfaces.
3. Their presence is a key diagnostic feature for identifying HPV-related dysplasia or carcinoma.
4. Koilocyte detection is critical for early diagnosis and management of cervical precancerous lesions.
5. The term 'koilocyte' derives from the Greek word 'koilos,' meaning hollow, reflecting their cytoplasmic changes.

Review Questions

Related terms

Pap smear:

A screening procedure for cervical cancer that involves collecting cells from the cervix.

HPV (Human Papillomavirus):

A viral infection that affects skin and mucous membranes and is closely associated with cervical cancer.

Cervical dysplasia: The presence of abnormal cells on the surface of the cervix that could potentially develop into cervical cancer.