Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
Fluconazole is an antifungal medication used to treat various fungal infections. It works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes.
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Fluconazole is commonly used to treat Candida infections, including those affecting the mouth, throat, and genitals.
It is effective against cryptococcal meningitis, a severe fungal infection of the nervous system.
Fluconazole can be administered orally or intravenously depending on the severity and location of the infection.
Unlike some other antifungal medications, fluconazole has good penetration into cerebrospinal fluid, making it useful for treating central nervous system infections.
Resistance to fluconazole can occur, especially in immunocompromised patients or with prolonged use.