Ergosterol is a sterol component found in fungal cell membranes, similar to cholesterol in animal cells. It is targeted by certain antifungal drugs due to its crucial role in maintaining cell membrane integrity.
5 Must Know Facts For Your Next Test
Ergosterol is essential for the structure and function of fungal cell membranes.
Many antifungal drugs, such as amphotericin B and azoles, target ergosterol or its biosynthesis.
Disruption of ergosterol can lead to increased membrane permeability and ultimately cell death.
Ergosterol is not found in animal cells, making it a selective target for antifungal therapy.
The synthesis of ergosterol involves multiple enzymatic steps that can be inhibited by specific drugs.