Fibrinogen-to-fibrin cascade

Definition

The fibrinogen-to-fibrin cascade is a biochemical process where the soluble plasma protein fibrinogen is converted into insoluble fibrin strands, forming a blood clot. This process is crucial for wound healing and preventing excessive blood loss.

5 Must Know Facts For Your Next Test

1. The conversion of fibrinogen to fibrin is catalyzed by the enzyme thrombin.
2. This cascade is an essential part of the coagulation pathway, which includes both intrinsic and extrinsic pathways.
3. Bacterial pathogens such as Staphylococcus aureus can manipulate this cascade to form protective barriers called biofilms.
4. Certain virulence factors, like coagulase produced by some bacteria, can activate the fibrinogen-to-fibrin conversion to evade host immune responses.
5. The regulation of this cascade involves various clotting factors and inhibitors, making it a tightly controlled process.

Review Questions

• What enzyme catalyzes the conversion of fibrinogen to fibrin?
• How do pathogens like Staphylococcus aureus utilize the fibrinogen-to-fibrin cascade?
• What role does coagulase play in bacterial virulence?

Related terms

Thrombin: An enzyme that converts fibrinogen into fibrin during the coagulation process.

Coagulase: An enzyme produced by certain bacteria that promotes blood clotting by converting fibrinogen to fibrin.

Biofilm: A structured community of microbial cells enclosed in a self-produced polymeric matrix attached to an inert or living surface.