Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
dsRNA stands for double-stranded RNA, a molecule consisting of two complementary strands of RNA. It is often involved in the replication and lifecycle of certain viruses.
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dsRNA is commonly found in the genomes of some RNA viruses such as reoviruses.
The presence of dsRNA in a cell can trigger antiviral immune responses, including RNA interference (RNAi).
dsRNA is recognized by host cells as a sign of viral infection, leading to the production of interferons.
Many viruses have evolved mechanisms to avoid detection by host cells by hiding or modifying their dsRNA.
dsRNA can be used experimentally to silence gene expression through a process known as RNA interference.