Chronic GVHD

Definition

Chronic Graft-Versus-Host Disease (GVHD) is a long-term complication that can occur after an allogeneic stem cell or bone marrow transplant, where the donor's immune cells attack the recipient's tissues. It typically develops more than 100 days post-transplant and can affect multiple organs.

5 Must Know Facts For Your Next Test

1. Chronic GVHD is characterized by symptoms such as skin rashes, liver dysfunction, and gastrointestinal issues.
2. Risk factors for chronic GVHD include older age of the donor or recipient and a mismatched donor-recipient pair.
3. The pathophysiology involves both cellular and humoral immune responses against host tissues.
4. Treatment often includes immunosuppressive drugs to reduce the immune response.
5. Early diagnosis and intervention are crucial to manage symptoms and improve quality of life.

Review Questions

Related terms

acute GVHD:

A form of graft-versus-host disease that occurs within the first 100 days after transplantation.

immunosuppressive therapy: Medications used to suppress the immune system to prevent graft rejection or treat autoimmune diseases.

allogeneic transplant: A procedure where a person receives stem cells from a genetically similar, but not identical, donor.