Acute GVHD

Definition

Acute Graft-Versus-Host Disease (GVHD) is a condition where donor immune cells attack the recipient's tissues following an organ or bone marrow transplant. It typically occurs within the first 100 days post-transplant.

5 Must Know Facts For Your Next Test

1. Acute GVHD primarily affects the skin, liver, and gastrointestinal tract.
2. It is classified into grades I to IV based on severity.
3. The risk of acute GVHD increases with greater HLA mismatches between donor and recipient.
4. Symptoms include rash, jaundice, diarrhea, and abdominal pain.
5. Immunosuppressive therapy is commonly used to prevent or treat acute GVHD.

Review Questions

Related terms

Chronic GVHD:

A form of graft-versus-host disease occurring more than 100 days post-transplant.

Immunosuppression:

The reduction of immune system activity to prevent transplant rejection or treat autoimmune diseases.

HLA Matching: The process of matching human leukocyte antigens between donor and recipient to reduce transplant rejection risk.