Acute GVHD
Definition
Acute Graft-Versus-Host Disease (GVHD) is a condition where donor immune cells attack the recipient's tissues following an organ or bone marrow transplant. It typically occurs within the first 100 days post-transplant.
5 Must Know Facts For Your Next Test
- Acute GVHD primarily affects the skin, liver, and gastrointestinal tract.
- It is classified into grades I to IV based on severity.
- The risk of acute GVHD increases with greater HLA mismatches between donor and recipient.
- Symptoms include rash, jaundice, diarrhea, and abdominal pain.
- Immunosuppressive therapy is commonly used to prevent or treat acute GVHD.
Review Questions
- What organs are most commonly affected by acute GVHD?
- How is the severity of acute GVHD classified?
- What factors increase the risk of developing acute GVHD?
"Acute GVHD" appears in:
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Related terms
Chronic GVHD: A form of graft-versus-host disease occurring more than 100 days post-transplant.
Immunosuppression: The reduction of immune system activity to prevent transplant rejection or treat autoimmune diseases.
HLA Matching: The process of matching human leukocyte antigens between donor and recipient to reduce transplant rejection risk.
