Cefazolin

Definition

Cefazolin is a first-generation cephalosporin antibiotic used to treat bacterial infections, particularly those caused by Gram-positive organisms. It is often employed in surgical prophylaxis and for treating skin, soft tissue, and blood infections.

5 Must Know Facts For Your Next Test

1. Cefazolin is effective against Staphylococcus aureus and Streptococcus species.
2. It functions by inhibiting bacterial cell wall synthesis, leading to cell lysis.
3. Administered parenterally, cefazolin has good tissue penetration, making it useful for serious systemic infections.
4. Commonly used as a prophylactic antibiotic before surgeries to prevent postoperative infections.
5. Cefazolin has a relatively long half-life compared to other first-generation cephalosporins, allowing for less frequent dosing.

Review Questions

Related terms

Cephalosporins:

A class of antibiotics structurally related to penicillins that target bacterial cell wall synthesis.

Staphylococcus aureus:

A type of Gram-positive bacteria frequently targeted by cefazolin.

Surgical Prophylaxis: The use of antibiotics before surgery to prevent postoperative infections.