C-reactive protein

Definition

C-reactive protein (CRP) is a substance produced by the liver in response to inflammation. It is commonly used as a biomarker to assess levels of systemic inflammation in the body.

5 Must Know Facts For Your Next Test

1. CRP levels increase rapidly within hours of infection or tissue damage.
2. High CRP levels are associated with bacterial infections, chronic inflammatory diseases, and cardiovascular conditions.
3. CRP is an acute-phase protein, meaning its plasma concentrations change significantly in response to inflammation.
4. The liver produces CRP under the influence of cytokines such as IL-6.
5. CRP can activate the complement system, part of the innate immune response.

Review Questions

• What triggers the production of C-reactive protein in the body?
• How quickly do CRP levels rise following an inflammatory event?
• What role does CRP play in the innate immune system?

Related terms

Complement System:

A group of proteins that work together to destroy pathogens and activate other immune responses.

Cytokines:

Small proteins released by cells that have a specific effect on interactions and communications between cells.

Acute-phase Proteins: Proteins whose plasma concentrations increase or decrease in response to inflammation.