BSL-4

Definition

BSL-4 (Biosafety Level 4) is the highest level of biological safety containment. It is used for work with highly dangerous and exotic pathogens that pose a high risk of aerosol-transmitted infections and for which there are no available vaccines or treatments.

5 Must Know Facts For Your Next Test

1. BSL-4 laboratories require complete isolation from other areas and strict control measures, including full-body positive pressure suits.
2. Agents handled in BSL-4 labs include viruses such as Ebola, Marburg, and Lassa fever.
3. BSL-4 facilities often have specialized ventilation systems and waste management practices to prevent contamination.
4. Only trained personnel with specific clearance are allowed to enter BSL-4 labs due to the high-risk nature of the pathogens.
5. Research in BSL-4 labs focuses on understanding pathogen behavior, developing diagnostics, treatments, and vaccines.

Review Questions

• What level of biosafety is required for handling highly dangerous pathogens like the Ebola virus?
• Name two primary safety features found in BSL-4 laboratories.
• Why are only specially trained personnel allowed access to BSL-4 labs?

Related terms

BSL-3: Biosafety Level 3 involves work with indigenous or exotic agents that may cause serious or potentially lethal diseases through inhalation.

Positive Pressure Suit: A protective suit designed to provide a barrier between the wearer and their environment, used in BSL-4 labs.

Pathogen: A microorganism that can cause disease in its host.