Basophils

Definition

Basophils are a type of white blood cell that play a role in immune responses, primarily by releasing histamine during allergic reactions and inflammatory processes. They are also involved in defense mechanisms against parasites.

5 Must Know Facts For Your Next Test

1. Basophils contain granules that store histamine and heparin, which are released during immune responses.
2. They represent less than 1% of the total white blood cell count in the human body.
3. Basophils have surface receptors for IgE antibodies, making them key players in allergic reactions.
4. They can trigger inflammation by releasing cytokines and other mediators.
5. Basophils share similarities with mast cells but circulate in the bloodstream, whereas mast cells reside in tissues.

Review Questions

• What substances do basophil granules contain and release during an immune response?
• How do basophils contribute to allergic reactions?
• What is the primary difference between basophils and mast cells regarding their location?

Related terms

Histamine:

A compound released by cells in response to injury and allergic reactions, causing contraction of smooth muscle and dilation of capillaries.

IgE Antibodies: A class of antibodies produced by the immune system that function mainly to combat parasitic infections and play a significant role in allergic diseases.

Mast Cells:

Cells found in connective tissues that release histamine and other substances during inflammatory and allergic responses.