HMDB - Human Metabolome Database

Definition

The Human Metabolome Database (HMDB) is a comprehensive online resource that provides detailed information about the small molecule metabolites found in the human body. This database plays a crucial role in metabolomics by offering data related to metabolite identification, biological functions, and associated diseases, allowing researchers to better understand human metabolism and its implications in health and disease.

5 Must Know Facts For Your Next Test

1. HMDB contains information on over 40,000 metabolites, including their structures, functions, and metabolic pathways.
2. The database provides links to relevant literature, experimental data, and disease associations for each metabolite, making it a valuable resource for researchers.
3. HMDB is continuously updated to include new findings and maintain accuracy, reflecting advances in the field of metabolomics.
4. The database allows users to search for metabolites based on various criteria, such as chemical structure, molecular weight, and metabolic pathways.
5. HMDB is used not only for academic research but also for clinical applications, helping in the discovery of novel biomarkers for diseases.

Review Questions

• How does the HMDB facilitate research in metabolomics?
  • The HMDB facilitates research in metabolomics by providing a centralized platform that contains extensive data on a wide range of human metabolites. This includes detailed information about their chemical structures, functions, and biological pathways. Researchers can utilize this resource to identify metabolites associated with specific conditions or diseases, which is essential for advancing our understanding of human metabolism and developing potential therapeutic strategies.
• Discuss the importance of HMDB in identifying biomarkers related to diseases.
  • The HMDB plays a vital role in identifying biomarkers related to diseases by offering comprehensive data that links specific metabolites to various health conditions. By analyzing these connections, researchers can uncover potential biomarkers that indicate the presence or progression of diseases. This information not only aids in diagnosis but also supports the development of targeted treatments and personalized medicine approaches.
• Evaluate how advancements in analytical techniques like mass spectrometry have influenced the evolution and utility of HMDB.
  • Advancements in analytical techniques such as mass spectrometry have significantly influenced the evolution and utility of HMDB by enhancing the accuracy and efficiency of metabolite identification. These techniques allow for the rapid analysis of complex biological samples, generating large datasets that feed into the database. As more data becomes available through improved methodologies, HMDB can offer updated and more comprehensive insights into human metabolism, thereby expanding its use as a crucial tool in both research and clinical settings.

Related terms

Metabolomics:

The scientific study of chemical processes involving metabolites, focusing on the comprehensive analysis of metabolites in biological samples.

Biomarkers: Biological molecules found in blood, other body fluids, or tissues that indicate a normal or abnormal process or condition.

Mass Spectrometry: An analytical technique used to measure the mass-to-charge ratio of ions, commonly used in metabolomics for the identification and quantification of metabolites.