OSPF, or Open Shortest Path First, is a link-state routing protocol used to determine the best path for data packets as they travel across an IP network. It is widely used in large enterprise networks due to its efficiency in routing and ability to quickly adapt to changes in the network topology. OSPF allows routers to share information about the network, enabling them to construct a complete map of the network and make informed routing decisions based on the current state of the network links.