Intro to Computational Biology
Well-tempered metadynamics is a computational technique used to explore the free energy landscape of molecular systems by gradually filling in the energy wells with Gaussian biasing potentials. This method allows for more accurate estimates of free energy profiles by controlling the height of the Gaussians and enabling better sampling of the relevant conformational space without getting trapped in local minima.
congrats on reading the definition of well-tempered metadynamics. now let's actually learn it.