Custer's Last Stand refers to the Battle of Little Bighorn, fought on June 25-26, 1876, where Lieutenant Colonel George Armstrong Custer and his forces were decisively defeated by a coalition of Native American tribes, primarily the Lakota Sioux and Cheyenne. This battle epitomizes the fierce conflicts between Native Americans and U.S. military forces during the westward expansion and highlights the growing tensions and resistance against settlers encroaching on Native lands.