Non-competitive antagonism refers to a type of drug interaction where an antagonist reduces the effect of an agonist by binding to a site other than the agonist's active site, thereby preventing the receptor from producing its maximal response. This type of antagonism affects the efficacy of the agonist without altering its binding affinity, leading to a decrease in the overall response even if the agonist is present. This concept is crucial for understanding how different drugs interact and can affect dose-response relationships.
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