Nicotinic acetylcholine receptors (nAChRs) are a type of neurotransmitter receptor that responds to the neurotransmitter acetylcholine as well as nicotine. These receptors are ionotropic, meaning they form an ion channel pore that allows the passage of ions like sodium and calcium, which leads to depolarization of the neuron. In the context of brain reward pathways, nAChRs play a crucial role in modulating neurotransmitter release and are involved in processes such as reinforcement, addiction, and reward-related behaviors.
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