Waardenburg Syndrome is a genetic disorder that primarily affects pigmentation and can result in hearing loss. It arises due to mutations in genes involved in the development and migration of neural crest cells, which play a crucial role in forming various tissues, including skin, hair, and the inner ear. This syndrome exemplifies the importance of neural crest cell migration and differentiation, as disruptions in these processes can lead to characteristic features such as changes in skin color, hair pigmentation, and auditory deficits.
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