Down-regulation
from class: Biology for Non-STEM Majors Definition Down-regulation is the process by which a cell decreases the quantity of a cellular component, such as a receptor, in response to an external stimulus. This mechanism helps prevent overstimulation and maintains cellular homeostasis.
congrats on reading the definition of down-regulation . now let's actually learn it.
Predict what's on your test 5 Must Know Facts For Your Next Test Down-regulation often occurs in response to high levels of hormones or neurotransmitters. It can decrease the sensitivity of cells to hormones, thus reducing their effects. Receptor down-regulation is a common mechanism in endocrine signaling pathways. This process can involve internalization and degradation of receptors or decreased receptor synthesis. Long-term exposure to certain drugs can lead to down-regulation of receptors, contributing to drug tolerance. Review Questions What is the primary purpose of down-regulation in cells? How does down-regulation affect cell sensitivity to hormones? What are two mechanisms by which down-regulation can occur? "Down-regulation" also found in:
© 2024 Fiveable Inc. All rights reserved. AP® and SAT® are trademarks registered by the College Board, which is not affiliated with, and does not endorse this website.