Chromosome inversion

Definition

Chromosome inversion is a genetic mutation where a segment of a chromosome is reversed end to end. This can affect gene function and regulation depending on the location of the inversion.

5 Must Know Facts For Your Next Test

1. Chromosome inversions can be pericentric (including the centromere) or paracentric (excluding the centromere).
2. Inversions can lead to reduced fertility due to complications during meiosis.
3. They do not involve any loss or gain of genetic material, just a rearrangement.
4. Inversions can suppress recombination in the inverted segment during meiosis.
5. Some inversions are known to be associated with certain diseases or disorders.

Review Questions

• What are the two types of chromosome inversions and how do they differ?
• How can chromosome inversions affect fertility?
• Why might an inversion suppress recombination during meiosis?

Related terms

Translocation: A chromosomal abnormality where segments from two different chromosomes have been exchanged.

Deletion: A mutation in which a part of a chromosome or a sequence of DNA is lost during DNA replication.

Duplication: A mutation that involves the production of one or more copies of any piece of DNA, including sometimes entire genes.