The solvent effect refers to the influence that a solvent has on the properties and behavior of solutes, particularly in chemical reactions and molecular interactions. This effect can significantly alter reaction rates, equilibrium constants, and the stability of intermediates by stabilizing or destabilizing certain molecular structures through solvation interactions. Understanding solvent effects is crucial for accurately modeling chemical systems using explicit solvent models and Quantum Mechanics/Molecular Mechanics (QM/MM) approaches.
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