Sertoli cells

Definition

Sertoli cells are specialized cells found within the seminiferous tubules of the testes. They play a crucial role in supporting and nourishing developing sperm cells through spermatogenesis.

5 Must Know Facts For Your Next Test

1. Sertoli cells form the blood-testis barrier, which protects germ cells from harmful substances.
2. They secrete inhibin, a hormone that regulates FSH levels in the blood.
3. Sertoli cells provide structural support and nutrients to developing spermatozoa.
4. They produce androgen-binding protein (ABP) which concentrates testosterone in the seminiferous tubules.
5. Sertoli cells phagocytize residual cytoplasm during spermiogenesis, aiding in sperm maturation.

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Related terms

Leydig Cells: Cells located in the testes that produce testosterone in response to LH stimulation.

Spermatogenesis: The process of producing mature spermatozoa from spermatogonial stem cells within the seminiferous tubules.

Inhibin: A hormone secreted by Sertoli cells that inhibits FSH production by acting on the anterior pituitary gland.