Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
Sertoli cells are specialized cells found within the seminiferous tubules of the testes. They play a crucial role in supporting and nourishing developing sperm cells through spermatogenesis.
5 Must Know Facts For Your Next Test
Sertoli cells form the blood-testis barrier, which protects germ cells from harmful substances.
They secrete inhibin, a hormone that regulates FSH levels in the blood.
Sertoli cells provide structural support and nutrients to developing spermatozoa.
They produce androgen-binding protein (ABP) which concentrates testosterone in the seminiferous tubules.
Sertoli cells phagocytize residual cytoplasm during spermiogenesis, aiding in sperm maturation.
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Related terms
Leydig Cells: Cells located in the testes that produce testosterone in response to LH stimulation.
Spermatogenesis: The process of producing mature spermatozoa from spermatogonial stem cells within the seminiferous tubules.
Inhibin: A hormone secreted by Sertoli cells that inhibits FSH production by acting on the anterior pituitary gland.