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PrPsc is an abnormal, pathogenic form of the prion protein. It is responsible for causing transmissible spongiform encephalopathies (TSEs) in humans and animals.
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PrPc: The normal cellular form of the prion protein that can be converted into PrPsc.
Transmissible Spongiform Encephalopathies (TSEs): A group of progressive conditions that affect the brain and nervous system in humans and animals.
Creutzfeldt-Jakob Disease (CJD): A rare, degenerative, fatal brain disorder caused by prions.