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Physiological dead space

Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025

Definition

Physiological dead space is the portion of the respiratory system where gas exchange does not occur, including both anatomical dead space and any alveoli that are not functioning properly. This space contributes to inefficiencies in breathing by reducing the amount of oxygen that reaches the bloodstream.

5 Must Know Facts For Your Next Test

  1. Physiological dead space includes anatomical dead space plus any non-functional alveoli.
  2. It can be increased in conditions such as pulmonary embolism or chronic obstructive pulmonary disease (COPD).
  3. The measurement of physiological dead space helps assess the efficiency of ventilation.
  4. A higher physiological dead space means less effective gas exchange and potential hypoxemia.
  5. It is typically measured using a combination of tidal volume, arterial blood gases, and expired CO2 levels.

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