Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
Neurodegenerative disorders are conditions characterized by the progressive degeneration of the structure and function of the nervous system. These disorders often lead to debilitating symptoms, including motor dysfunction and cognitive decline.
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Alzheimer's disease is one of the most common neurodegenerative disorders, primarily affecting memory and cognitive abilities.
Parkinson's disease involves the loss of dopamine-producing neurons in the brain, leading to motor control issues such as tremors and rigidity.
Amyotrophic Lateral Sclerosis (ALS) affects motor neurons and leads to muscle weakness and atrophy.
Neurodegenerative disorders often involve abnormal protein aggregation, such as amyloid plaques in Alzheimer's disease.
These disorders are currently incurable, but treatments can help manage symptoms and improve quality of life.
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Related terms
Alzheimer's Disease: A neurodegenerative disorder that primarily affects memory and cognitive function due to beta-amyloid plaque build-up.
Parkinson's Disease: A disorder characterized by the degeneration of dopamine-producing neurons leading to motor dysfunction.
Amyotrophic Lateral Sclerosis (ALS): A progressive neurodegenerative disease that affects motor neurons, causing muscle weakness and atrophy.