Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
Interstitial fluid is the liquid found between cells in tissues, providing a medium for nutrients and waste to be exchanged. It plays a crucial role in maintaining the internal environment of tissues.
5 Must Know Facts For Your Next Test
Interstitial fluid makes up about 16% of an adult human's body weight.
It is derived from blood plasma but lacks most of the proteins found in plasma.
Interstitial fluid helps transport nutrients, oxygen, and waste products between blood and cells.
The composition of interstitial fluid can affect cellular function and signaling.
Lymph eventually returns interstitial fluid to the circulatory system.
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Related terms
Blood Plasma: The liquid component of blood that carries cells and proteins throughout the body.
Lymphatic System: A network of tissues and organs that help rid the body of toxins and waste through lymph.
Extracellular Matrix: A complex network of proteins and carbohydrates surrounding cells, providing structural support.