Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
Intercellular signaling is the process by which cells communicate with each other through signaling molecules and receptors. This communication is essential for coordinating various cellular activities and responses.
5 Must Know Facts For Your Next Test
Intercellular signaling can be classified into autocrine, paracrine, endocrine, and juxtacrine signaling based on the distance the signal travels.
Signaling molecules include hormones, neurotransmitters, and cytokines which bind to specific cellular receptors.
The binding of a signaling molecule to its receptor initiates a signal transduction pathway leading to a specific cellular response.
G-protein coupled receptors (GPCRs) are a common type of receptor involved in intercellular signaling.
Disruption in intercellular signaling pathways can lead to diseases such as cancer, diabetes, and autoimmune disorders.
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Related terms
Autocrine Signaling: A form of cell communication where a cell targets itself with signaling molecules.
Paracrine Signaling: A form of cell communication where cells signal nearby cells within a close proximity.
Endocrine Signaling: A form of long-distance cell communication involving hormones that travel through the bloodstream to reach target cells.