Insulin-like growth factors (IGFs)

Definition

Insulin-like growth factors (IGFs) are hormones with a similar molecular structure to insulin. They play a crucial role in growth and development, especially during childhood.

5 Must Know Facts For Your Next Test

1. IGFs are primarily produced in the liver in response to growth hormone (GH) stimulation.
2. They mediate many of the growth-promoting effects of growth hormone.
3. IGF-1 is the most studied form and is vital for muscle and bone growth.
4. Insufficient or excessive levels of IGF can lead to various health issues, including stunted growth or gigantism.
5. IGFs interact with specific receptors on cell surfaces to initiate cellular responses related to proliferation and differentiation.

Review Questions

Related terms

Growth Hormone (GH): A peptide hormone that stimulates growth, cell reproduction, and regeneration.

Insulin:

A hormone produced by the pancreas that regulates blood glucose levels.

Receptor:

A protein molecule that receives chemical signals from outside a cell.