Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
Diacylglycerol (DAG) is a lipid-derived molecule that acts as a second messenger in cellular signal transduction pathways. It is produced by the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) and activates protein kinase C (PKC).
5 Must Know Facts For Your Next Test
DAG is generated from the cleavage of PIP2 by the enzyme phospholipase C (PLC).
It remains in the plasma membrane due to its hydrophobic nature.
DAG activates protein kinase C (PKC), which phosphorylates target proteins to propagate cellular signals.
It works in conjunction with another second messenger, inositol trisphosphate (IP3), to regulate intracellular calcium levels.
DAG plays a crucial role in various cellular processes, including cell growth, differentiation, and metabolism.
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Related terms
Phosphatidylinositol 4,5-bisphosphate (PIP2): A phospholipid found in the plasma membrane that is cleaved by PLC to produce DAG and IP3.
Protein Kinase C (PKC): An enzyme activated by DAG that phosphorylates specific target proteins involved in signal transduction.
Inositol trisphosphate (IP3): A second messenger produced alongside DAG from PIP2 cleavage that helps release calcium ions from intracellular stores.