General Biology I

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Cyclins

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General Biology I

Definition

Cyclins are proteins that regulate the progression of the cell cycle by activating cyclin-dependent kinases (CDKs). They ensure that cell cycle events occur in the correct sequence and at the appropriate time.

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5 Must Know Facts For Your Next Test

  1. Cyclins bind to CDKs, forming a complex that drives the cell through specific stages of the cell cycle.
  2. Different types of cyclins are active at different phases of the cell cycle (e.g., G1/S cyclins, S cyclins, M cyclins).
  3. The levels of cyclins fluctuate throughout the cell cycle; they are synthesized and degraded as needed.
  4. Cyclin-CDK complexes can be regulated by phosphorylation and dephosphorylation events.
  5. Dysregulation of cyclin levels can lead to uncontrolled cell division and is often implicated in cancer.

Review Questions

  • What role do cyclins play in regulating the cell cycle?
  • How do cyclin levels change throughout the cell cycle?
  • Why is the regulation of cyclin-CDK complexes important for proper cell division?
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