Back mutations

Definition

Back mutations are genetic changes that restore the original sequence and function of a gene that had previously undergone mutation. These can occur naturally or be induced in a laboratory setting.

5 Must Know Facts For Your Next Test

1. Back mutations can revert a virus to its wild-type form, potentially impacting treatment strategies.
2. They may occur spontaneously or through selective pressure, such as the use of antiviral drugs.
3. Back mutations can complicate vaccine development as they might lead to loss of vaccine efficacy.
4. Laboratory studies often induce back mutations to study viral resistance mechanisms and potential treatments.
5. The rate of back mutation can vary depending on the virus and environmental conditions.

Review Questions

• What is a back mutation and how does it affect viral genetics?
• How can back mutations impact the effectiveness of antiviral treatments?
• Why are back mutations significant in the context of vaccine development?

Related terms

Forward Mutation: A genetic alteration that changes a wild-type allele to a new variant.

Antiviral Resistance: The ability of a virus to withstand the effects of an antiviral drug.

Genetic Reversion: The process by which a mutated gene returns to its original state.