Aminopeptidase

Definition

Aminopeptidase is an enzyme that catalyzes the cleavage of amino acids from the amino end of polypeptides. It plays a crucial role in protein digestion by breaking down peptides into free amino acids for absorption.

5 Must Know Facts For Your Next Test

1. Aminopeptidases are found in the brush border of the small intestine.
2. They specifically remove terminal amino acids from the amino end of peptide chains.
3. These enzymes aid in the final stages of protein digestion after initial breakdown by pepsin and trypsin.
4. Aminopeptidases are essential for the absorption of nutrients as free amino acids are more readily absorbed than peptides.
5. Inhibition or deficiency of aminopeptidase activity can lead to malabsorption and nutritional deficiencies.

Related terms

Pepsin:

An enzyme in the stomach that begins protein digestion by breaking down proteins into smaller peptides.

Trypsin: An enzyme produced in the pancreas and released into the small intestine to further digest peptides into smaller units.

Brush Border Enzymes: Enzymes located on the microvilli of intestinal epithelial cells that complete digestion of carbohydrates and proteins.