Acetylcholinesterase
Definition
Acetylcholinesterase is an enzyme that breaks down the neurotransmitter acetylcholine in the synaptic cleft. It plays a crucial role in terminating synaptic transmission and allowing muscle relaxation.
5 Must Know Facts For Your Next Test
- Acetylcholinesterase is located at neuromuscular junctions and cholinergic brain synapses.
- It hydrolyzes acetylcholine into acetate and choline, which are then recycled.
- Inhibition of acetylcholinesterase can lead to prolonged muscle contractions and potentially fatal respiratory paralysis.
- Acetylcholinesterase activity ensures that muscles do not remain in a constant state of contraction.
- Some nerve agents and pesticides function by inhibiting acetylcholinesterase.
Review Questions
- What role does acetylcholinesterase play at the neuromuscular junction?
- What are the products of acetylcholine breakdown by acetylcholinesterase?
- How does inhibition of acetylcholinesterase affect muscle function?
"Acetylcholinesterase" appears in:
Study guides (1)
Related terms
Term: Acetylcholine
Term: Neuromuscular Junction
Term: Cholinergic Synapse
