Cell and Tissue Engineering

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Wettability

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Cell and Tissue Engineering

Definition

Wettability refers to the ability of a liquid to maintain contact with a solid surface, resulting from intermolecular interactions between the liquid and solid. It is commonly described using the contact angle formed between the liquid droplet and the solid surface; a smaller contact angle indicates better wettability. Wettability plays a crucial role in various applications, influencing processes such as adhesion, surface modification, and the behavior of biomaterials in biological environments.

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5 Must Know Facts For Your Next Test

  1. Wettability is influenced by both the chemical composition and the roughness of the solid surface.
  2. Surfaces can be engineered to be superhydrophobic or superhydrophilic by manipulating their chemical properties or microstructure.
  3. Wettability affects cell behavior, including adhesion, spreading, and proliferation, making it crucial for tissue engineering applications.
  4. The measurement of contact angles can provide insight into surface energy and interactions, which are vital for predicting how materials will behave in different environments.
  5. Changes in wettability can impact the performance of coatings, drug delivery systems, and other biomedical applications.

Review Questions

  • How does wettability influence cell behavior in tissue engineering?
    • Wettability significantly affects cell behavior such as adhesion, spreading, and proliferation on biomaterial surfaces. A more hydrophilic surface tends to promote better cell adhesion and spreading, which are essential for tissue integration and regeneration. On the other hand, hydrophobic surfaces may hinder cell attachment and lead to reduced cellular activity. Understanding these interactions allows for the design of biomaterials that can better support desired cellular responses.
  • Discuss the importance of measuring contact angles when assessing material surfaces in biomedical applications.
    • Measuring contact angles is crucial in evaluating material surfaces because it provides insight into their wettability characteristics. This information helps predict how biological fluids will interact with the material, which is essential for applications like implants or drug delivery systems. By understanding the surface energy and interactions through contact angle measurements, researchers can modify surfaces to achieve desired levels of hydrophilicity or hydrophobicity, improving compatibility with biological environments.
  • Evaluate how manipulating surface properties can affect wettability and its implications for material design in engineering applications.
    • Manipulating surface properties, such as chemistry and roughness, can dramatically affect wettability and thus alter how materials interact with liquids. For example, creating micro- or nanoscale textures on a surface can lead to superhydrophobic properties that repel water. This manipulation is vital for engineering applications where controlling liquid behavior is necessaryโ€”like in self-cleaning surfaces or improving fluid flow in microfluidic devices. The implications extend to enhancing performance in medical devices where optimized wettability can improve biocompatibility and function.
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