Noesy, or Nuclear Overhauser Effect Spectroscopy, is a powerful NMR technique that enhances the signal of nuclei through cross-relaxation effects between nearby spins. This method is particularly useful in structural biology for determining spatial relationships between atoms in macromolecules, providing insights into their three-dimensional structures. By exploiting the interactions between non-bonded hydrogen atoms, noesy allows researchers to gather information about molecular dynamics and conformational states.
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