Messenger RNA (mRNA)

Definition

Messenger RNA (mRNA) is a type of RNA that carries genetic information from DNA to the ribosome, where proteins are synthesized. It plays a crucial role in the process of transcription and translation, acting as a template for assembling amino acids into proteins based on the sequence of nucleotides. This process is essential for gene expression and regulation, linking the genetic code in DNA to the functional proteins needed for cellular processes.

5 Must Know Facts For Your Next Test

1. mRNA is synthesized during transcription when RNA polymerase binds to the DNA template and constructs a complementary RNA strand.
2. After transcription, mRNA undergoes processing, including capping, polyadenylation, and splicing, to become a mature mRNA molecule ready for translation.
3. Each mRNA molecule contains codons, which are sequences of three nucleotides that specify particular amino acids during protein synthesis.
4. mRNA has a relatively short lifespan in the cell, as it is eventually degraded after its role in protein synthesis is complete, allowing for tight regulation of gene expression.
5. In eukaryotes, mRNA must exit the nucleus through nuclear pores to reach the cytoplasm where translation occurs.

Review Questions

• How does mRNA function in the processes of transcription and translation?
  • mRNA serves as a bridge between DNA and protein synthesis. During transcription, it is created from the DNA template by RNA polymerase. Once formed, mRNA carries the genetic code from the nucleus to the ribosomes in the cytoplasm. There, during translation, ribosomes read the mRNA's codons to assemble amino acids into proteins, effectively translating the genetic instructions into functional molecules.
• What role does mRNA processing play in ensuring proper protein synthesis?
  • mRNA processing includes several modifications such as capping at the 5' end, polyadenylation at the 3' end, and splicing out introns. These modifications are essential for protecting mRNA from degradation, facilitating its export from the nucleus to the cytoplasm, and ensuring that only the coding sequences (exons) are translated into proteins. This processing enhances the stability and efficiency of mRNA during translation.
• Evaluate how variations in mRNA can influence protein diversity and gene regulation.
  • Variations in mRNA can significantly impact protein diversity through alternative splicing and differing polyadenylation sites, leading to multiple protein isoforms from a single gene. This adds complexity to gene regulation, as different isoforms may have distinct functions or regulatory roles within a cell. Additionally, changes in mRNA levels or stability can influence how much protein is produced in response to cellular signals, allowing cells to adapt to changing environments effectively.

Related terms

Transcription: The process by which the genetic information in DNA is copied into mRNA, which occurs in the nucleus of eukaryotic cells.

Translation: The process by which ribosomes read the mRNA sequence and synthesize proteins by linking together the appropriate amino acids.

Ribosome: A complex molecular machine found within all living cells that facilitates the translation of mRNA into proteins.