🇪🇺ap european history review

Smallpox Vaccination

Written by the Fiveable Content Team • Last updated September 2025
Verified for the 2026 exam
Verified for the 2026 examWritten by the Fiveable Content Team • Last updated September 2025

Definition

Smallpox vaccination refers to the immunization process that uses a live vaccinia virus to provide immunity against smallpox, a highly contagious and deadly disease caused by the variola virus. This practice marked a significant advancement in medical science during the Age of Enlightenment, showcasing early efforts to understand disease causation and public health in a rapidly changing society.

5 Must Know Facts For Your Next Test

  1. The first successful smallpox vaccination by Edward Jenner in 1796 led to the eventual eradication of smallpox, declared by the WHO in 1980.
  2. Smallpox vaccination was revolutionary as it shifted medical practice towards preventative care and understanding infectious diseases.
  3. The use of vaccination challenged existing medical beliefs and practices, leading to debates over the safety and ethics of immunization.
  4. Smallpox was responsible for millions of deaths before the development of the vaccination, highlighting the need for effective public health measures.
  5. Vaccination campaigns in the 18th century laid the groundwork for modern public health initiatives and vaccination programs worldwide.

Review Questions

  • How did Edward Jenner's development of the smallpox vaccination impact medical practices in the 18th century?
    • Edward Jenner's development of the smallpox vaccination had a profound impact on medical practices in the 18th century by introducing a new approach focused on prevention rather than treatment. It marked a shift towards understanding infectious diseases and establishing immunization as a standard practice in medicine. The success of Jenner's method encouraged further research into vaccines, ultimately leading to advancements in public health and preventive medicine.
  • In what ways did the introduction of smallpox vaccination challenge existing beliefs about disease and treatment during this period?
    • The introduction of smallpox vaccination challenged existing beliefs by promoting the idea that diseases could be prevented through immunization rather than solely treated once contracted. This contradicted traditional practices such as bloodletting and herbal remedies that dominated medicine at the time. Vaccination raised ethical questions about its safety and effectiveness, igniting debates among medical professionals and the public regarding new approaches to health care.
  • Evaluate the broader implications of smallpox vaccination for society during the Age of Enlightenment, especially concerning public health initiatives.
    • Smallpox vaccination had significant implications for society during the Age of Enlightenment by fostering a greater understanding of public health and disease management. As vaccination became recognized as an essential tool for preventing epidemics, it laid the groundwork for systematic public health initiatives. The success of smallpox vaccination not only contributed to the eventual eradication of the disease but also influenced global health policies, emphasizing the importance of preventive measures and collective responsibility for community health.

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