Written by the Fiveable Content Team • Last updated September 2025
Verified for the 2026 exam
Verified for the 2026 exam•Written by the Fiveable Content Team • Last updated September 2025
Definition
A sulfhydryl group (-SH) is a functional group consisting of a sulfur atom bonded to a hydrogen atom. It can be found in some amino acids and proteins.
These are organic compounds composed mainly from carbon, hydrogen, oxygen, and nitrogen atoms. Some also contain sulfur atoms (like those with sulfhydryl groups).
These are covalent bonds that can form between two cysteine residues in a protein due to the interaction of their sulfhydryl groups. It's like the bond formed when you press together two pieces of velcro!